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With the development of SC injection devices, the paradigm of drug product development has continued to shift towards patient centricity by enabling self-administration and ease of use for patients, improving compliance and adherence and reducing the burden on healthcare systems.1 The number of approved monoclonal antibody (mAb) products has been increasing over the last few decades, with a proportional increase in the number of SC products (Figure 1), based on the information compiled by ten23 health on US FDA-approved products

When this process is impaired, dysfunctional mitochondria accumulate, ROS rises, and inflammatory signaling is engagedfeatures linked to neurodegeneration [83, 84]

Changes in lipid, glutamine, and iron metabolism are related to ferroptosis sensitivity

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